A review on different vitamin K1-3 effects on hepatocellular cancer and their tumour cell biology mechanism indicate possible synergistic treatment strategies. Monitoring of dysfunctional carboxylation of the vitamin K dependent coagulation factor II, with the commercial ELISA test PIVKA-II has been used as a hepatocellular cancer marker. Its relevance is also reviewed. Currently the PIVKA-II test has been withdrawn due to marketing reasons by Stago.
Keywords: Vitamin K; Menaquinone; Hepatocellular cancer; Hepatitis; Cirrhosis; PIVKA-II
Published on: Sep 26, 2017 Pages: 49-52
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DOI: 10.17352/ahr.000017
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