What Successes can be Expected in the Fight Against Infection in Acute Pneumonia in the Context of the Side Effects of Antimicrobial Therapy?

Igor Klepikov*

Acute pneumonia (AP) is still one of the most unpredictable and dangerous inflammatory diseases, even with significant progress in antimicrobial treatment. This review looks at how medical understanding and treatment of AP have changed over time. It focuses on the side effects and limitations of long-term antibiotic use. The analysis uses both historical and modern literature to show how the germ theory of disease and the reliance on antibiotics have created current misunderstandings about the causes and treatment of AP. The paper discusses the rise of antibiotic resistance, the changing nature of pneumonia germs, and the increasing occurrence of viral pneumonia in the post-antibiotic era. It also argues that the focus on antimicrobials has caused us to overlook the mechanisms related to the host’s response. By bringing together evidence from a century of microbiological and clinical studies, the author calls for a shift in thinking. We need to look beyond antibiotics as the only treatment and adopt a broader view of the mechanisms behind AP. The review ends by stating that if we do not reevaluate the role of microbial factors and the limits of antibiotics, progress in treating pneumonia will remain limited. 

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Published on: Nov 7, 2025 Pages: 17-21

Full Text PDF Full Text HTML DOI: 10.17352/aprc.000093
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